Defesa de Dissertação de Mestrado – Nicholas Roberto Drabowski – 06/08/2018
06/08/2018 17:23
| Defesa de Dissertação de Mestrado | |
| Aluno | Nicholas Roberto Drabowski |
| Orientador | Prof. Alexandre Trofino Neto, Dr. – DAS/UFSC |
| Data | 06/08/2018 (segunda-feira) – 14h00
Sala PPGEAS II (piso inferior) |
| Banca | Prof. Alexandre Trofino Neto, Dr. – Presidente – DAS/UFSC;
Prof. Jefferson Brum Barques, Dr. – EEL/UFSC; Prof. Marcelo Ricardo Stemmer, Dr. – DAS/UFSC; Prof. Schubert Carvalho, Dr. – ITV/PA; Prof. Cleison Daniel Silva, Dr. – UFPA. |
| Título | Modulation of Cortical Electrical Activity by Deep Brains Stimulation of the Amygdala in Rats |
| Abstract: Deep brain stimulation (DBS) is an alternative of treatment for refractory psychiatric disorders that still faces the challenge of correctly configuring the stimulation parameters for each patient individually. Closed-loop DBS systems can be developed to improve the DBS pro- gramming. The amygdala (AMY) is a limbic structure that plays a key role in several psychiatric illnesses, therefore being a key structure for DBS stimulation. The medial prefrontal cortex (mPFC) is reciprocally connected to AMY and its modulation by AMY DBS may be useful for the development of closed-loop DBS systems. The effect of acute AMY DBS on mPFC modulation and its effects on anxiety-like behavior reduc- tion were investigated in wistar rats. The brain signals acquired from rats subjected to DBS were analyzed using the Power Spectral Density, Poincare Map and Correlation Dimension. The calculation of correlation between 112 features acquired from the previous analysis revealed the existence of two biomarkers that were used for anxiety-like behavior assessment. The results suggest that AMY DBS can be used as a mean to reduce anxiety. Since technological difficulties with the performed experiments reduced the number of subjects that could be taken into account in this study, it is still important to check the generality of the above results for a larger number of subjects. The anxiety biomarkers proposed may be useful for the development of closed-loop DBS treat- ments applied to the limbic system in psychiatric diseases, since the anxiety plays a key role in many psychiatric diseases. | |
